Opportunity Information: Apply for PA 19 124
The Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed), NIH funding opportunity number PA 19-124, is a discretionary grant program aimed at bringing established quantitative scientists and engineers more directly into NIH-relevant biomedical, behavioral, and health-related research. The core idea is to support productive professionals whose prior work has been primarily rooted in quantitative or engineering disciplines, but not yet centered on questions of human health and disease. Through this award, NIH is essentially investing in the transition of these researchers into health-focused research careers by giving them structured mentorship, formal and informal training, and protected time to build the domain knowledge and collaborations needed to apply their technical expertise to health problems.
A defining feature of this K25 mechanism is that it is a mentored career development award. Rather than funding an independent research program immediately, it supports a period of supervised study and research under the guidance of an experienced mentor (or mentoring team). The expectation is that the candidate will use this mentored period to expand their understanding of biomedical and clinical context while adapting or extending quantitative methods to address NIH-relevant questions. The announcement explicitly highlights backgrounds such as mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry, and engineering, reflecting NIH's interest in methods development and cross-disciplinary innovation that can improve how health and disease are measured, modeled, understood, predicted, or treated.
This specific parent FOA is tailored for applicants who are not proposing to lead an independent clinical trial. It is designed for research plans that do not involve serving as the lead investigator for an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. However, it still allows a candidate to gain clinical trial-related experience if that work is conducted within a trial led by the mentor or co-mentor. In other words, you can be involved in clinical trial research as part of your training and research experience, but you cannot be the person responsible for leading the trial under this particular FOA. Applicants who intend to lead a clinical trial or ancillary clinical trial as the primary investigator are directed to apply to the companion FOA that permits that structure.
Eligibility for applicant organizations is broad and reflects NIH's typical institutional landscape for grants. Eligible applicants include various levels of government (state, county, city/township, and special district), federally recognized Native American tribal governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3), excluding higher education institutions in those nonprofit categories), for-profit organizations (other than small businesses), and small businesses. The FOA also calls out additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, it draws a clear boundary around foreign applications: non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as the applicant organization. That said, "foreign components" as defined by the NIH Grants Policy Statement are allowed, meaning parts of the proposed project may involve foreign collaborations or activities when justified and structured consistent with NIH policy, even though the applicant institution itself must be domestic.
From an administrative perspective, the sponsoring agency is the National Institutes of Health, and the funding instrument is a grant. The activity category is listed under education, health, income security and social services, consistent with the career development and training emphasis of K awards. The FOA is associated with multiple CFDA numbers (now generally referred to as Assistance Listing numbers), including 93.121, 93.173, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.846, 93.855, 93.865, and 93.866, reflecting that various NIH Institutes and Centers may participate and support K25 awards across different mission areas. The opportunity record shows an original closing date of May 7, 2020, and a creation date of December 20, 2018; award ceiling and expected awards are not specified in the provided source data.
In practical terms, the opportunity is best understood as a bridge for quantitatively trained researchers to become competitive, health-focused investigators by combining their technical strengths with a mentored plan for developing biomedical expertise, an NIH-relevant research direction, and a trajectory toward research independence. The program prioritizes the integration of rigorous quantitative or engineering methods into health and disease research while placing clear limits on independent clinical trial leadership under this particular announcement.Apply for PA 19 124
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.846, 93.855, 93.865, 93.866.
- This funding opportunity was created on 2018-12-20.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (PA 19 124) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 19 126 Funding Number: PA 19 126 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Required) Apply for PA 19 129 Funding Number: PA 19 129 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) Apply for PAR 19 135 Funding Number: PAR 19 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) Apply for PAR 19 163 Funding Number: PAR 19 163 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| HIV/AIDS Clinical Trials Networks Laboratory Centers (UM1 Clinical Trial Required) Apply for RFA AI 19 001 Funding Number: RFA AI 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV Prevention Clinical Trials Network Leadership and Operations Center (UM1 Clinical Trial Required) Apply for RFA AI 19 005 Funding Number: RFA AI 19 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV/AIDS Clinical Trials Networks Statistical and Data Management Centers (SDMC) (UM1 Clinical Trial Required) Apply for RFA AI 19 002 Funding Number: RFA AI 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (R01 Clinical Trial Optional) Apply for RFA AI 19 022 Funding Number: RFA AI 19 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $350,000 |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (U01 Clinical Trial Optional) Apply for RFA AI 19 023 Funding Number: RFA AI 19 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
| BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 135 Funding Number: RFA MH 20 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Secondary Analysis and Archiving of BRAIN Initiative Data (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 120 Funding Number: RFA MH 20 120 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Brain Initiative: Research to Develop and Validate Advanced Human Cell-Based Assays To Model Brain Structure and Function (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 140 Funding Number: RFA MH 20 140 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| "Clinical Trials" on a Chip: Tissue Chips to Inform Clinical Trial Design and Implementation in Precision Medicine (UG3/UH3 - Clinical Trial Not Allowed) Apply for RFA TR 19 014 Funding Number: RFA TR 19 014 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trial Not Allowed) Apply for RFA EB 19 001 Funding Number: RFA EB 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01 Clinical Trial not allowed) Apply for RFA EB 19 002 Funding Number: RFA EB 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Science of Behavior Change (SOBC) Resource and Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA AG 20 024 Funding Number: RFA AG 20 024 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01 Clinical Trial Optional) Apply for RFA MH 20 310 Funding Number: RFA MH 20 310 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Clinical Sites for the ECHO IDeA States Pediatric Clinical Trials Network - 2 (UG1 Clinical Trial Required) Apply for RFA OD 19 026 Funding Number: RFA OD 19 026 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $275,000 |
| Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed) Apply for PAR 19 375 Funding Number: PAR 19 375 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional) Apply for PAR 19 376 Funding Number: PAR 19 376 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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