Opportunity Information: Apply for RFA HD 17 017
The NIH funding opportunity titled "Developmental Mechanisms of Human Structural Birth Defects (P01)" (RFA-HD-17-017; CFDA 93.865) supports large, team-based Program Project Grant (P01) applications aimed at explaining how major congenital structural malformations arise. The central emphasis is on understanding developmental biology and genetic causes of significant human birth defects by bringing together basic science, translational work, and clinical research in a tightly integrated way. The FOA is designed for projects where collaboration is not just beneficial but essential, meaning the different parts of the program are expected to interact, share expertise and resources, and produce a combined outcome that is stronger than three independent studies.
A defining feature of this FOA is its required structure. Each funded program project must include exactly three component research projects plus the necessary shared cores. The three projects must be unified by one clear central theme and should converge on a specific major developmental defect or malformation. The defect under study must be meaningfully comparable between humans and the chosen animal model(s), whether the similarity is genetic (shared causal genes or variants), mechanistic (shared developmental pathways), biological (shared tissue or organ development processes), or phenotypic (similar observable malformation features). The FOA explicitly allows either mammalian or non-mammalian model systems, as long as the model is relevant to the shared scientific question and strengthens the overall program.
The FOA also sets clear expectations for the scientific balance across the three projects. At least one component project must be basic research conducted in an animal model system, and at least one component project must be clinical or translational in nature. In other words, applicants need to demonstrate a full pipeline that connects fundamental developmental mechanisms to human disease understanding, such as linking animal-model experiments on embryologic processes to human patient data, clinical phenotyping, genomics, or translational studies that move discoveries toward improved diagnosis, risk assessment, or mechanistic interpretation of human variants.
To reinforce integration, the three projects are expected to share more than a general topic area. They should be connected by a common developmental gene, biological process, mechanism, pathway, or phenotype. This requirement pushes applicants to design a coordinated program where each project answers a different part of a single overarching problem, for example: one project defining how a pathway shapes organ development in an animal model, another identifying or validating human genetic variants affecting that pathway, and a third translating those insights into improved clinical interpretation, genotype-phenotype relationships, or patient stratification. The shared cores are intended to support these cross-project needs, such as shared genomics, bioinformatics, imaging, phenotyping, model organism resources, or biostatistics, depending on what best enables synergy.
Eligibility is broad and includes many U.S.-based organizational types such as public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses as well as small businesses), and multiple levels of government (state, county, city/township, special districts), as well as certain housing authorities and tribal entities. The FOA also highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions are not eligible to apply as applicant organizations, and non-U.S. components of U.S. organizations are not eligible. However, foreign components as defined under the NIH Grants Policy Statement are allowed, meaning a U.S. applicant can include certain well-justified international collaborations or resources within NIH policy limits.
Administratively, this is an NIH discretionary grant opportunity using the P01 program project mechanism within the health-related funding category. The original closing date listed is 2016-12-16, with an anticipated number of awards of about two. The overarching goal is to fund a small number of highly integrated, high-impact programs that can meaningfully advance understanding of the mechanisms and genetic architecture of important human structural birth defects by deliberately connecting model organism discovery science with human clinical and translational investigation.Apply for RFA HD 17 017
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Developmental Mechanisms of Human Structural Birth Defects (P01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2016-08-15.
- Applicants must submit their applications by 2016-12-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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