Opportunity Information: Apply for RFA AA 23 002
The Comprehensive Alcohol Research Centers (P60 Clinical Trial Optional) funding opportunity (RFA-AA-23-002) is an NIH discretionary grant program designed to build and sustain large, coordinated alcohol research centers. It uses the NIH P60 Comprehensive Research Center mechanism, which is meant for long-term, multi-investigator, multidisciplinary programs that are organized around a single, clearly defined major research theme. In practice, this mechanism supports not just individual research projects, but an integrated center structure that combines multiple lines of research with shared resources and research support activities, all aligned to advance a focused alcohol-related scientific agenda. The "clinical trial optional" designation indicates that the proposed research program may include clinical trials, but clinical trials are not required to be part of the application.
The main purpose of the opportunity is to support an organized research center that can tackle complex alcohol-related problems in a broad-based way, bringing together different disciplines and investigators under one coordinated program. The emphasis is on integration and synergy: the expectation is that the center is more than a collection of separate projects, and instead functions as a unified program where the combined effort, shared infrastructure, and coordinated leadership produce outcomes that would be difficult to achieve through isolated grants. Because the FOA highlights both research and research support activities, applicants should expect to propose center-level components that facilitate collaboration, shared methods or cores, and sustained productivity around the center theme.
The sponsoring agency is the National Institutes of Health, and the funding activity category is Health under CFDA number 93.273. The award ceiling listed is $1,250,000, signaling that awards may support substantial center operations and multiple research components under one umbrella. The original closing date for applications was 2023-11-15, and the FOA was created on 2023-05-24.
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants listed include state, county, city or township governments, special district governments, independent school districts, and federally recognized Native American tribal governments. Higher education institutions are eligible as well, including public or state-controlled institutions of higher education and private institutions of higher education. A wide range of nonprofit organizations may apply, including those with 501(c)(3) status and those without 501(c)(3) status (in both cases, other than institutions of higher education). For-profit organizations other than small businesses are eligible, as are small businesses, public housing authorities/Indian housing authorities, and Native American tribal organizations other than federally recognized tribal governments. The FOA also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.
At the same time, the FOA places clear limits on foreign participation. Non-domestic (non-U.S.) entities classified as foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S. applicant organization may be able to include certain foreign activities or collaborations if they meet NIH's definition and requirements for foreign components, even though a foreign institution cannot serve as the applicant organization.
Overall, this opportunity is aimed at applicants that can demonstrate the leadership, infrastructure, and collaborative capacity to run a comprehensive alcohol research center with a coherent, high-impact theme, integrating multiple investigators and disciplines, potentially including but not requiring clinical trials, and supported by center-level resources that enable sustained, coordinated progress in alcohol research.Apply for RFA AA 23 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Comprehensive Alcohol Research Centers (P60 Clinical trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on 2023-05-24.
- Applicants must submit their applications by 2023-11-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,250,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Comprehensive Alcohol Research Centers (P60 Clinical Trial Optional) opportunity?
This is an NIH discretionary grant program (RFA-AA-23-002) that supports the creation and long-term operation of large, coordinated alcohol research centers using the NIH P60 Comprehensive Research Center mechanism.
What does the NIH P60 mechanism support in practice?
The P60 mechanism is designed for long-term, multi-investigator, multidisciplinary research programs organized around one clearly defined major research theme. It supports an integrated center structure, not only individual projects, by combining multiple lines of research with shared resources and research support activities aligned to a focused alcohol-related scientific agenda.
Is this funding meant for a single research project or a full research center?
It is meant for a full research center. The expectation is a coordinated program with multiple research components and center-level infrastructure, rather than a set of unrelated projects bundled together.
What is the main purpose of this funding opportunity?
The purpose is to build and sustain an organized alcohol research center that can address complex alcohol-related problems in a broad-based way by bringing together investigators and disciplines under one coordinated program.
What does the FOA mean by "integration and synergy"?
Integration and synergy means the center should function as a unified program where shared infrastructure, coordinated leadership, and collaboration across projects produce outcomes that would be difficult to achieve through isolated grants.
What kinds of activities are expected beyond individual research projects?
The FOA emphasizes both research and research support activities. Applicants should expect to propose center-level components that facilitate collaboration and sustained productivity, such as shared methods, cores, or other shared resources that support the center theme.
Are clinical trials required?
No. The FOA is designated "clinical trial optional," meaning the proposed research program may include clinical trials, but clinical trials are not required as part of the application.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What is the funding activity category and CFDA number?
The funding activity category is Health, and the CFDA number listed is 93.273.
What is the award ceiling for this opportunity?
The award ceiling listed is $1,250,000, indicating support can be substantial enough to cover center operations and multiple coordinated components under one umbrella.
When was the FOA created and when did it close?
The FOA was created on 2023-05-24, and the original closing date for applications was 2023-11-15.
What types of U.S. government entities are eligible to apply?
Eligibility includes state, county, city or township governments, special district governments, independent school districts, and federally recognized Native American tribal governments.
Are higher education institutions eligible?
Yes. Public or state-controlled institutions of higher education and private institutions of higher education are eligible applicants.
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofit organizations with 501(c)(3) status and nonprofit organizations without 501(c)(3) status (in both cases, other than institutions of higher education).
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also eligible.
Are housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are tribal organizations eligible if they are not federally recognized tribal governments?
Yes. The eligibility list includes Native American tribal organizations other than federally recognized tribal governments, and it also calls out Indian/Native American tribal governments other than federally recognized.
Which institution types are explicitly called out as eligible?
The FOA explicitly calls out eligibility for Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included in the listed applicant categories.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly listed among eligible applicants.
Can a foreign institution apply as the applicant organization?
No. Non-domestic (non-U.S.) entities classified as foreign institutions are not eligible to apply.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply.
Are any types of foreign participation allowed at all?
Yes. Foreign components are allowed as defined by the NIH Grants Policy Statement. This means a U.S. applicant organization may be able to include certain foreign activities or collaborations if they meet NIH's definition and requirements for foreign components, even though a foreign institution cannot be the applicant.
What kind of applicant is this program aimed at?
This opportunity is aimed at applicants that can demonstrate the leadership, infrastructure, and collaborative capacity to run a comprehensive alcohol research center with a coherent, high-impact theme that integrates multiple investigators and disciplines, supported by shared center resources.
What is the central organizing requirement of the research center?
The center should be organized around a single, clearly defined major research theme focused on alcohol-related science, with coordinated research and support components aligned to that theme.
What makes a proposed center competitive based on the description provided?
Based on the description, the emphasis is on a coordinated, integrated program (not separate projects), with shared infrastructure and leadership that enables sustained collaboration and productivity around a focused alcohol-related scientific agenda, with the option (but not requirement) to include clinical trials.
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