Opportunity Information: Apply for RFA MH 23 335
The NIH BRAIN Initiative funding opportunity "Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)" (RFA-MH-23-335) supports projects that can measure human behavior with far greater precision and then tightly connect those behavioral measurements to brain activity recorded at the same time. The central idea is that behavior is often measured in ways that are too coarse or inconsistent to match the sophistication of modern human neuroscience tools (for example, high-density electrophysiology, advanced neuroimaging, stimulation and modulation methods, or other circuit-level recording approaches). This program is aimed at closing that gap by funding next generation behavior-quantification platforms and analytics that are accurate, specific, temporally precise, and flexible enough to align with the kinds of measurements used to study the neural circuits that generate behavior.
The opportunity emphasizes multi-modal behavioral measurement and analysis rather than single-channel approaches. In practice, this means applicants are expected to think beyond one data stream (such as only video or only wearables) and instead design tools and pipelines that can combine and interpret multiple types of behavioral signals. Examples of relevant modalities could include video-based movement and posture tracking, audio and speech features, eye tracking and gaze dynamics, digital interaction patterns, physiological signals that reflect behaviorally relevant state, and other sensor-derived measures. The key requirement is not just collecting more data, but producing behavioral representations that can be meaningfully linked to brain activity, with timing and specificity strong enough to support mechanistic inference rather than broad correlations.
This is a phased innovation award using the R61/R33 structure. The R61 phase is intended for early-stage development and validation of novel tools, which can include hardware, software, or integrated platforms and analytic methods. During this phase, teams typically establish feasibility, demonstrate that the approach can reliably quantify targeted behaviors, and show that the tool is on a credible path toward robust use in humans. The R33 phase focuses on synchronization and integration, meaning the developed behavioral tools should be aligned in time and use with simultaneously acquired human brain activity data. The intent is that, by the R33 stage, the project has moved beyond prototypes and is demonstrating that behavioral quantification can be co-registered with neural recordings in a way that is technically sound and scientifically useful, enabling downstream studies of brain-behavior relationships with high temporal fidelity.
The "Clinical Trial Optional" designation signals that applications may include clinical trial elements if appropriate, but a clinical trial is not required. This provides flexibility for teams whose work involves testing the tool in participant groups, clinical populations, or real-world settings where behavioral measurement and concurrent brain recording might be evaluated. At the same time, it allows purely methods-focused projects to apply without forcing a clinical trial structure when it is not necessary for tool development and validation.
Eligible applicants are broad, reflecting NIH's intent to attract interdisciplinary and cross-sector teams that can combine neuroscience, engineering, computer science, human factors, and clinical expertise. Eligible organizations include state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other applicant types. The announcement also explicitly calls out additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, HBCUs, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This wide eligibility scope supports participation from groups with strong community ties, unique populations, specialized technical capabilities, or international expertise relevant to measuring behavior and brain function in humans.
Administratively, the sponsor is the National Institutes of Health, and the opportunity falls under a discretionary grant mechanism. The original closing date listed is February 15, 2024, and the opportunity is associated with multiple CFDA/assistance listing numbers (93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867), reflecting the multi-institute, cross-cutting nature often seen in BRAIN Initiative efforts. The overall program can be understood as an investment in measurement infrastructure: building the behavioral "side" of brain-behavior science so that it is synchronized, quantitative, and scalable enough to match the rapid advances in tools for recording and modulating the human brain.Apply for RFA MH 23 335
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2022-12-22.
- Applicants must submit their applications by 2024-02-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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